Ideally it should not be a critical mass issue, but one of utility. A tag for "information" would be extremely populated but of little value, and a tag for "inverse relations" would specify - I trust - a very limited set, but also be of little value.
That said, if a very small number of questions related to a very salient topic, do they deserve a tag due to projection of further population of the set or strictly because of their salience? How many questions that happen to contain a given topic make it worthwhile to create a tag connecting them?